The Hawkins Lab is a part of the Division of Medical Genetics in the Department of Medicine, and the Department of Genome Sciences at the University of Washington School of Medicine. We are also members of the Institute for Stem Cell & Regenerative Medicine (ISCRM). The lab began in October, 2010.
We currently have a Postdoctoral Fellow position available for a computational biologist or bioinformatic scientist to specialize in cis-regualtory genomics and epigenomics. This position is for an NIH-funded project through the 4D Nucleome consortium focused on investigating 2D gene regulation and 3D genome architecture, and the relationship to autoimmune diseases/disorders. We are studying disease-associated variants within cis-regulatory elements (CREs; such as enhancers) using massively parallel reporter assays and chromatin QTL mapping (ATAC-seq) from donor samples, and identifying CRE target genes using 3D genome architecture (Hi-C based methods). We are using bulk and single-cell approaches to tackle this challenge. CRISPR editing in primary T cells is used for validation studies. The successful applicant will have the opportunity to lead on this project and to collaborate with our colleagues using functional system immunology as validation.
Candidates should have experience in epigenomics, gene regulation and/or immunology. Demonstrable skills in bioinformatic and data visualization are required. Good written and verbal communication skills are required. Experience with single-cell genomics preferred. Must be highly motivated, but can’t take yourself too seriously, and get along well with others.
The Hawkins Lab is part of the Division of Medical Genetics, Department of Medicine and the Department of Genome Sciences, and members of the Institute for Stem Cell and Regenerative Medicine. The University of Washington is a world-class research institute with state-of-the-art facilities and services. The Seattle area is home to a thriving research community, which includes Benaroya Research Institute, Fred Hutchinson Cancer Research Center, the Institute for Systems Biology, the Allen Institutes, Sage Bionetworks, and others. The city of Seattle is a vibrant place to live surrounded by Lake Washington and the Puget Sound, with the Cascade and Olympic mountain ranges nearby. Seattle is home to foodies, geeks, hipsters, nerds, techies, artists, coffee snobs, and nature-loving, hiking, ski/snowboarding enthusiasts. Come make the most of your postdoc.
Email CV, research background and interest to Dr. Hawkins.
Please note that if you are an international applicant the University of Washington does not sponsor H1B visas, only J1s. Sorry, this is their policy not mine.
Lab Location: K-wing of Magnuson Health Sciences Building (HSB) - K226:
Office Location: K236B
Office Phone: 206.543.3619
Lab Phone: 206.685.8314
Lab Email (general requests): hawkinslab
2020 - early 2021- So many things were missed and not posted here due the pandemic...
09.19.19 - Congrats to Arpit on a fun collaboration with the Lieber lab online in Molecular Therapy.
05.08.19 - Congrats to Thomas and Stephanie on DNA methylation changes with superovulation in the early mouse embryo. Out now in Epigenetics. Another fun project with Bo Yu's lab.
05.02.19 - Congrats to Stephanie et al. (so many lab contributions on this one). This is finally published. Great work on epigenomics and 3D genome architecture in naive hESCs in Stem Cell Reports.
11.26.18 - Congrats to Cristina, Naresh and Colin! Nice collaboration with the Avraham lab out today in Scientific Reports on dynamic DNA methylation changes during inner ear development.
07.02.18 - Nice collaboration with Lieber lab out in Blood. Thanks Cristina.
03.01.18 - Looking forward to collaboration with Drechsler lab at Western University on an awarded USDA-AFRI grant!
02.20.18 - Elyn Fritz-Waters joins the lab. Welcome!
01.22.18 - Eric Waddle joins the lab. Welcome!
11.17.17 - Introducing Dr. Battle. Congrats to Stephanie on a well defended thesis!
09.30.17 - Arpit's review on 3D genome architecture and disease is out now in Genome Medicine. Nice job!
09.15.17 - Congrats to Thomas on his Genome Training Grant!
09.01.17 - Congrats to Cristina for her effort on our ongoing collaboration with the Ruohola-Baker lab, out in PNAS. Protein engineering to disrupt PRC2 in ESCs.
08.24.17 - Congrats to Kalyan and Naresh, with help from Colin and Stephanie. Age and culture induced methylation changes at enhancers in bone marrow MSCs is out in Stem Cell Reports. Way to go!
08.08.17 - Congrats to Cristina, Colin and Naresh. Nice job on the 3D neural rosette epigenomic landscapes! Out today in Cell Reports.
07.11.17 - Happy to be collaborating with new faculty at UW, Bo Yu. See the amazing work on human oocytes in Stem Cell Reports.
06.19.17 - Thomas Smith joins the lab. Welcome!
06.08.17 - Congrats to Eliah on her Amazon Catalyst grant!
04.13.17 - Thanks to Cristina and Colin again for the collaborative efforts with the Otonkoski lab. Out now in Cell Reports.
04.12.17 - Congrats to Colin on getting into NYU!
03.20.17 - Arpit Mishra joins the lab. Welcome.
02.14.17 - Check out Colin's contribution the the Chamberlain lab paper out in Nature Communications.
08.20.16 - Eliah Overbey, GS grad student, joins the lab!!!
06.10.16 - Have a look at Stephanie's contribution to our collaboration with Su-In Lee's lab in Genome Medicine.
03.01.16 - Congrats to Kalyan on his co-first author paper out in Scientific Reports, and to Cristina, a co-author. Nice job everyone!
01.14.16 - Genetics vs reprogramming: what makes iPSCs epigenetically different? Check out our contribution to the answer through a collaboration with Timo Otonkoski's group, out now in Stem Cell Reports.
01.04.16 - Ajay Jajodia joins the lab.
12.21.15 - Congrats to Cristina et al. on her development of cChIP-seq - a great method for small-scale ChIP-seq of histone mods! Check it out in BMC Genomics. I'm convinced 10k cells isn't the lower limit. Stay tuned.
12.08.15 - More work on T cells out in Genome Medicine.
11.16.15 - Great study linking the metabolome and epigenome in naïve human ESCs from our collaboration with the Ruohola-Baker lab out in Nature Cell Biology. Thanks to Stephanie and Cristina for their effort!
07.31.15 - The lab was awarded an R01 from NIH/NIDDK.
06.29.15 - Check out Enna's contribution to our collaboration with the Akey lab in Genome Research.
04.20.15 - Robert Azad joins the lab.
04.16.15 - Naresh Doni Jayavelu joins the lab via Turku.
04.03.15 - Happy to have contributed to the Papapetrou lab's paper out in Nature Biotech.
03.23.15 - Congratulations to Stephanie Battle on her fellowship from the Ford Foundation!
03.16.15 - The lab received an award from the UW Royalty Research Fund.
03.15.15 - See our review on Epigenomics of Autoimmune Diseases.
03.01.15 - The lab was awarded an R01 from NIH/NIAMS.