Research
We use an integrative analysis of histone modifications, open chromatin, 3D genome architecture, DNA methylation and expression of RNAs to understand gene regulation through epigenetic mechanisms.
We are interested in how cell states are defined and regulated. Stem and progenitor cells have to the unique ability to give rise to other cells in the human body. However, these cells have the same genetic make up as their differentiated daughter cells. We would like to understand how cell fates are defined and how the epigenome contributes to the developmental plasticity of these cells.
In addition, we study how genetic variants at cis-regulatory elements alter their activity. Employing methods such as massively
parallel reporter assays, capture Hi-C and CRISPR genome editing, we are functionally validating CRE activity, the effect of
variants, and identifying CRE-target genes.
We are interested in how cell states are defined and regulated. Stem and progenitor cells have to the unique ability to give rise to other cells in the human body. However, these cells have the same genetic make up as their differentiated daughter cells. We would like to understand how cell fates are defined and how the epigenome contributes to the developmental plasticity of these cells.
In addition, we study how genetic variants at cis-regulatory elements alter their activity. Employing methods such as massively
parallel reporter assays, capture Hi-C and CRISPR genome editing, we are functionally validating CRE activity, the effect of
variants, and identifying CRE-target genes.
